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Side effects produced by Synthroid include fatigue, increased appetite, weight loss, heat intolerance, and fever. People who are treated with Synthroid may initially lose some hair, but this effect is usually temporary. The most commonly prescribed of all the thyroid supplements. You have diabetes, Synthroid will tend to make your symptoms worse. Some foods also can affect how Synthroid is absorbed, such as soybean flour, cotton seed meal, and dietary fiber.