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Do not take Diflucan without first talking to your doctor if you have yeast infection, Diflucan is an oral antifungal agent that can be administered orally or parenterally. Diflucan comes as a tablet and liquid to take by mouth usually taken once a day. Fluconazole is a triazole antifungal agent that may be an easier treatment than a messy cream. Your order from the online pharmacy. Diflucan comes as a tablet and liquid to take by mouth. Fluconazole is a triazole antifungal agent that may be an easier treatment than a messy cream. Fluconazole disturbs the production of ergosterol that is essential component of the fungi cell, resulting in changing permeability.