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Individuals who have developed allergic reactions from aspirin or other NSAIDs may experience an allergic reaction to Celecoxib and should not take Celecoxib. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the liver. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. This medication should not be used if you have certain medical conditions. In osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Fluconazole increases the concentration of Celecoxib in the liver. For the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Individuals who have developed allergic reactions from aspirin or other NSAIDs may experience an allergic reaction to Celecoxib and should not take Celecoxib.