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If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal or as directed by your doctor. Glucophage is from the biguanide class of oral anti-hyperglycemic agents. Metformin decreases the amount of sugar produced by cells in the liver. Overall, Metformin reduces blood sugar levels. Overall, Metformin reduces blood sugar levels. Metformin can be used in combination with other anti-diabetic medicines to provide better control of blood sugar.