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Because this medication may actually increase your risk of stroke or blood clots. Conjugated estrogens? Long-term conjugated estrogens treatment may increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. What should I discuss with my healthcare provider before taking conjugated estrogens unless your doctor directs otherwise. What is the most important information I should know about conjugated estrogens? There are no restrictions on food, beverages, or activity while taking conjugated estrogens unless your doctor directs otherwise.