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If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal or as directed by your doctor. Diabetes in people who are overweight. Metformin belongs to the class of drugs known as biguanides. Metformin belongs to the class of drugs known as biguanides. Glucophage lowers the amount of sugar that your liver makes and that your stomach absorbs. Metformin increases the sensitivity of muscle cells to insulin. Glucophage is used to control blood sugar levels. Metformin also increases your body's proper response to the insulin you naturally produce, and by decreasing the amount of sugar produced by cells in the liver.