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Lexapro is used to treat depression. Do not take Escitalopram together with a monoamine oxidase inhibitor. Escitalopram is a selective serotonin reuptake inhibitors. Lexapro blocks the re-absorption of serotonin by the first nerve cell. Because Escitalopram appears to work by increasing the available supply of serotonin, a chemical messenger in the brain that helps maintain mental balance. Lexapro is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors.