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It should be noted that it is very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders. You could have unpleasant withdrawal symptoms. Prednisone has very little mineral corticoid activity, so it is not used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Prednisone most often is used for treating several types of arthritis systemic lupus, allergic reactions, asthma and severe psoriasis. Prednisone may interact with estrogens and phenytoin. Prednisone has very little mineral corticoid activity, so it is not used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. A dose adjustment or special tests to safely take Prednisolone. Prednisolone prevents the release of certain chemicals that are important in the immune system plays an important role.