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Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. Prednisone may interact with estrogens and phenytoin. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. Deltasone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Since prednisone is used in so many conditions, only the most common or established uses are mentioned here.